HISTORY OF SEDATIVE DRUGS – THEIR EVOLUTION IN MEDICINE

two. Histamine Receptor Antagonism: Some sedatives, such as antihistamines, exert their sedative effects by blocking histamine receptors inside the Mind, specifically H1 receptors. Histamine plays a role in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness.Supplements: Several nutritional supplements — which includ